秦冲

秦冲

博士

教授

博士生导师

科 室：

药物合成

电子邮箱：

qc@ouc.edu.cn

联系地址：

青岛市崂山区香港东路23号中国海洋大学浮山校区研究院C303

研究方向：

1. 基于靶向蛋白降解（PROTACs）策略的小分子先导化合物发现和新药发现

2. 去势抵抗性前列腺癌治疗药物研究

3. 海洋天然活性物质的结构多样性修饰及成药性优化

个人简介

       教授，博士生导师，青岛海洋生物医药研究院副院长。主持国家高层次青年人才项目（2021）、国家重点研发计划青年科学家项目（2022）、国家自然基金青年基金（2021）、山东省“泰山学者”青年专家（2020）、山东省自然基金优秀青年基金（2021）等研究项目，获北京市自然科学奖一等奖（2019）。近年来在 J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、J. Med. Chem. 等杂志发表学术论文二十余篇。

教育背景

2010.09~2015.07

北京大学

药物化学

博士 （导师：焦宁教授）

2006.09~2010.06

中国农业大学

应用化学

学士

工作经历

2019.09至今

中国海洋大学

教授

2016.01~2019.09

美国密歇根大学

博士后

导师：Shaomeng Wang

荣誉奖励

北京市自然科学奖一等奖（2019）

主讲《高等药物化学》研究生课程获教育部“拓金计划”示范课程（2022）、山东省研究生教育优质课程（2021）

北京大学学生五四奖章（2014）

课题组主页（The Qin Group @OUC）: http://qin.qdmbri.com/

ResearchGate: https://www.researchgate.net/profile/Chong-Qin-7

代表性成果

代表性论文(*corresponding author)：

Yan Lv⁺, Zixuan Yang⁺, Yiming Chen⁺, Xuepei Ma, Mengqi Guo, Chengwei Zhang, Xiaolin Jiang, Chengli Wang, Zhuoyue Li, Zhengfu Tai, Xiao Wang, Siqi Zhang*, Shumin Ma*, Chong Qin*. A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRAS^G12C Inhibitor. J. Med. Chem. 2024, 10.1021/acs.jmedchem.3c01598. (IF: 8.039).

Simin Sun⁺, Zhuoyue Li⁺, Chao Huang, Jinyu Liu, Qixin Yu, Xiaolin Jiang, Kairui Yue, Jianchun Zhao, Tongqiang Xu, Yankai Liu, Xiaoyang Li*, Chong Qin*, Yuqi Jiang*. Discovery of Novel 2,3-Dihydro-1H-indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis. J. Med. Chem. 2023, 66, 16141–16167. (IF: 8.039).

Zhuoyue Li⁺, Yiming Chen⁺, Xiaolin Jiang⁺, Penghui Lu, Chengli Wang, Zhimin Li, Xinyue Yu, Zixuan Yang, Shumin Ma, Shanshan Du, Zhengfu Tai, Xiaoyang Li*, Siqi Zhang*, Yuqi Jiang*, Chong Qin*. Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis. J. Med. Chem. 2023, 66, 12966–12989. (IF: 8.039).

Bowen Zhang⁺, Chang Liu⁺, Zhenqian Yang⁺, Sai Zhang⁺, Xiaolin Hu, Baohu Li, Mei Mao, Xiao Wang, Zhuoyue Li, Shumin Ma, Siqi Zhang, and Chong Qin*. Discovery of BWA-522, a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate Cancer. J. Med. Chem. 2023, 66, 11158-11186. (IF: 8.039)

Siqi Zhang⁺, Xiaolei Meng⁺, Sai Zhang⁺, Baohu Li, Wencong Jin, Chengwei Zhang, Zhaojuan Liu, Xiaolin Hu, Ling Ge, Zhonghao Yu, Zhuoyue Li, Shumin Ma, Xiao Wang, Liming Li, Chong Qin*. Design, Synthesis and Biological Evaluation of Androgen Receptor (AR) Antagonist-Heat Shock Protein 90 (Hsp90) Inhibitor Conjugates for Targeted Therapy of Castration-Resistant Prostate Cancer. J. Med. Chem. 2023, 66, 4784–4801. (IF: 8.039)

Liming Li⁺*, Heping Zheng⁺, Xuepei Ma, Jie Bai, Shumin Ma, Zhuoyue Li, Chong Qin*. Inhibition of Astrocytic Carbohydrate Sulfotransferase 15 Promotes Nerve Repair After Spinal Cord Injury via Mitigation of CSPG Mediated Axonal Inhibition. Cell. Mol. Neurobiol. 2023, 43, 2925–2937. (IF: 4.231)

Qiang Wang, Baohu Li, Wenkai Zhang, Zhuoyue Li, Bo Jiang*, Sichuan Hou*, Shumin Ma*, Chong Qin*, Lethal Activity of BRD4 PROTAC Degrader QCA570 Against Bladder Cancer Cells. Front. Chem. 2023, doi.org/10.3389/fchem.2023.1121724. (IF: 5.545)

Ruxuan Wang, Tengjiang Zhong, Qiong Bian, Sai Zhang, Xiaolu Ma, Liming Li, Yihua Xu, Yueting Gu, Anran Yuan, Weitong Hu, Chong Qin*, Jianqing Gao*, PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration. Small Methods. 2023, 7, 2201293. (IF: 14.188)

Chong Qin and Ning Jiao*, Iron-Facilitated Direct Oxidative C−H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles. J. Am. Chem. Soc. 2010, 132, 15893-15895;

Chong Qin, Wang Zhou, Feng Chen, Yang Ou and Ning Jiao*, Iron-catalyzed C-H and C-C Bond Cleavage: A Direct Approach to Amides from Simple Hydrocarbon Molecules, Angew. Chem. Int. Ed. 2011, 50, 12595-12599;

Chong Qin, Tao Shen, Conghui Tang and Ning Jiao*, FeCl₂-promoted Unactivated C-C Bond Cleavage of Alkylarenes and Polystyrene: Direct Synthesis of Versatile Arylamines, Angew. Chem. Int. Ed. 2012, 51, 6971-6975;

Chong Qin, Peng Feng, Yang Ou, Tao Shen, Teng Wang and Ning Jiao*, Highly Selective Csp²-Csp Bond Cleavage: The Nitrogenation of Alkynes to Amides. Angew. Chem. Int. Ed. 2013, 52, 7850-7854;

Chong Qin,⁺ Yijin Su,⁺ Xiaodong Shi and Ning Jiao*, Splitting a Substrate into Three Parts: Gold-Catalyzed Nitrogenation of Alkynes by C-C and C≡C Bond Cleavage. Angew. Chem. Int. Ed. 2016, 55, 350-354;

Chong Qin,⁺ Yang Hu,⁺ Bing Zhou,⁺... Shaomeng Wang*, Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J. Med. Chem. 2018, 61, 6685–6704;

项目课题

1. 国家高层次青年人才项目，300万，2022.1-2024.12，主持；

2. 国家重点研发计划青年科学家项目（2022YFC2804400），200万，2022.11-2025.10，主持；

3. 国家自然科学基金青年基金（22107095），30万，2022.1-2024.12，主持；

4. 山东省“泰山学者”青年专家（tsqn201909171），100万，2020.01-2024.12，主持；

5. 山东省自然科学基金优秀青年基金（22107095），40万，2022.1-2024.12，主持。