姜 帅 | 博士 | 教授 | 博士生导师 | ||
科 室: | 药剂室 | ||||
办公电话: | 15966871213 | 电子邮箱: | jiangshuai@ouc.edu.cn | ||
联系地址: | 山东省青岛市鱼山路5号中国海洋大学医药学院,邮编266003 | ||||
研究方向: | 1. 靶向药物递送与药物控释 2. 纳米-生物界面作用机制与调控策略 3. 糖类在靶向纳米制剂中的应用 | ||||
个人简介 |
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2021年5月受聘于中国海洋大学“青年英才工程”第一层次教授岗位,加入医药学院独立开展研究工作。主要从事纳米药物与纳米-生物界面作用的研究工作。课题组通过将传统纳米乳液技术与界面可控聚合反应相结合,开发药物的原位、高效包覆新技术,构建特异性智能纳米载体材料,实现对不同性质药物的安全、高效负载与可控释放;系统研究纳米材料与人体血液蛋白的吸附作用机制与调控策略,目标提高纳米药物的临床转化成功率。 近年来在国际权威学术期刊发表研究论文40余篇,其中以第一或通讯作者在Angew. Chem.、Adv. Funct. Mater.、ACS Nano、Nano Lett.、Acc. Chem. Res.、Nanoscale Horiz.等权威期刊上发表论文23篇,篇均影响因子9+;申请中国发明专利1项。Google scholar即时引用700+,h index 14。 Google Scholar: https://scholar.google.de/citations?user=QU1qNosAAAAJ&hl=en Researchgate: https://www.researchgate.net/profile/Shuai-Jiang-10
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教育背景 |
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2013.12~2015.11 | 德国马普学会高分子研究所 | 高分子物理化学 | 博士联培 | ||
2011.09~2016.06 | 中国科学院大学 山西煤炭化学研究所 | 工业催化 | 硕博连读 | ||
2007.09~2011.06 | 烟台大学 | 化学工程与工艺 | 学士 | ||
工作经历 |
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2021.05~至今 | 中国海洋大学医药学院 | 教授 |
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2019.09~2021.04 | 德国马普学会高分子所 | 课题组长 |
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2016.08~2019.08 | 德国马普学会高分子所 | 博士后 |
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学术兼职 |
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Frontiers in Materials期刊客座编辑。 | |||||
研究进展 |
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纳米药物靶向递释系统是一种极具开发潜力的药物递送策略,其通过改变药物的代谢动力学和组织分布,提高对肿瘤组织的特异性作用并同时降低药物对正常组织的毒性,在肿瘤治疗领域得到了广泛的重视和发展。针对现阶段抗肿瘤纳米药物临床转化率低的瓶颈问题,本课题组从(1)高效、智能药物纳米载体的设计与构建和(2)纳米-血液蛋白相互作用两方面开展研究工作。基于胶体化学和界面聚合,开发了纳米乳液原位包覆技术,针对特定药物的具体性质(如亲疏水性、生物活性与反应活性、分子尺寸、释药需求等),发展出一系列特异性纳米胶囊药物递释载体。结合材料表面修饰与表征、蛋白质组学和生物实验,建立了纳米材料-血液蛋白相互作用的研究方法学,重点研究了血液蛋白的吸附机制与调控方法,揭示了材料表面性质对蛋白质吸附及其生物学行为的影响,为纳米药物在肿瘤治疗中的高效、安全用药和临床转化提供了研究基础。 | |||||
代表性成果 | |||||
代表性论文(*通讯作者;+共同一作) |
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23.M. Prawatborisut, S. Jiang,* J. Oberländer, V.Mailänder, D. Crespy,* and K.Landfester. Modulating Protein Corona and Materials-Cell Interactions with Temperature-Responsive Materials. Adv. Funct. Mater.2021,DOI: 10.1002/adfm.202106353. (IF=18.808) 22.Li, M.; Jiang, S.;* Simon, J.; Paßlick, D.; Frey, M.; Wagner, M.; Mailänder, V.; Crespy, D.; Landfester, K.* Brush Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime. Nano Lett. 2021,21, 1591-1598. (IF=11.189) 21.Li, M.; Jiang, S.;* Haller, A.; Wirsching, S.; Fichter, M.; Simon, J.; Wagner, M.; Mailänder, M.; Gehring, S.; Crespy, D.; Landfester, K.* Encapsulation of polyprodrugs enables an efficient and controlled release of dexamethasone. Nanoscale Horiz. 2021,6, 791-800.(IF=10.989) --- - - - 20.Jiang, S.; Lv, L.-P.; Landfester, K.; Crespy, D., Nanocontainers in and onto Nanofibers. Acc. Chem. Res. 2016,49, 816-823. (IF=22.384) 19.Jiang, S.; Silva, L.; Ivanov, T.; Mottola, M.;Landfester, K.*Synthetic Silica Nano-Organelles for Regulation of Cascade Reactions in Multi-Compartmentalized Systems.Angew. Chem. Int. Ed.2021, DOI: 10.1002/anie.202113784. (IF=15.336) 18.Jiang, S.; Xiao, M., Sun, W., Crespy, D., Mailänder, V., Peng, X., Fan, J., Landfester, K. Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem ROS Generation.Angew. Chem. Int. Ed.2020,59, 2-11. (IF=15.336) 17. Huang, W.;+ Huber, N.;+ Jiang, S.;+Landfester, K.; Zhang, K. Covalent triazine framework nanoparticles via size-controllable confinement synthesis for enhanced visible light photoredox catalysis. Angew. Chem. Int. Ed.2020,59, 18368-18373. (IF=15.336, 共同一作) 16.Jiang, S.;Kaltbeitzel, A.; Hu, M.; Suraeva, O.; Crespy, D.; Landfester, K. One-Step Preparation of Fuel-Containing Anisotropic Nanocapsules with Stimuli-Regulated Propulsion. ACS Nano2019,14, 498-598. (IF=15.881) 15. Jiang, S.; Ma, B., Huang, W., Kaltbeitzel, A., Kizisavasa, G., Crespy, D., Zhang, K., and Landfester, K., Visible light active nanofibrous membrane for antibacterial wound dressing. Nanoscale Horiz.2018,3, 439-446. (IF=10.989) 14. Jiang, S.; Ma, B.; Reinholz, J.; Li, Q.; Wang, J.; Zhang, K.; Landfester, K.; Crespy, D. Efficient Nanofibrous Membranes for Antibacterial Wound Dressing and UV Protection. ACS Appl. Mater. Interfaces 2016,8, 29915-29922. (IF=9.229,引用>50次) 13. Jiang, S., Prozeller, D., Pereira, J., Simon, J., Han, S., Wirsching, S., et al. Controlling protein interactions in blood for effective liver immunosuppressive therapy by silica nanocapsules. Nanoscale2020,12, 2626-2637. (IF=7.790) 12. Jiang, S.; Lv, L.; Li, Q.; Wang, J.; Landfester, K.; Crespy, D. Tailoring nanoarchitectonics to control the release profile of payloads. Nanoscale2016,8, 11511-11517. (IF=7.790) 11. Jiang, S.; Li, Q.; Zhao, Y.; Wang, J.; Kang, M. Effect of surface silanization of carbon fiber on mechanical properties of carbon fiber reinforced polyurethane composites. Compos. Sci. Technol.2015,110, 87-94. (IF=8.520, 引用>100次) 10. Jiang, S.; Li, Q.; Wang, J.; He, Z.; Zhao, Y.; Kang, M. Multiscale graphene oxide-carbon fiber reinforcements for advanced polyurethane composites. Compos. Part A2016,87, 1-9. (IF=7.664,引用>50次) 9. Jiang, S., Mottola, M., Han, S., Thiramanas, R., Graf, R., Lieberwirth, I., et al. Versatile Preparation of Silica Nanocapsules for Biomedical Applications. Part. Part. Syst. Char.2020, 1900484. (IF=3.310) 8. Jiang, S.; Mable, C. J.; Armes, S. P.; Crespy, D. Directed Assembly of Soft Anisotropic Nanoparticles by Colloid Electrospinning. Macromol. Rapid Commun.2016,37, 1598-1602. (IF=5.734) 7. Jiang, S.; He, W.; Landfester, K.; Crespy, D.; Mylon, S. The structure of fibers produced by colloid-electrospinning depends on the aggregation state of particles in the electrospinning feed. Polymer 2017,127, 101-105. (IF=4.430) 6. Jiang,S.; Lieberwirth, I.; Landfester, K.; Muñoz-Espí, R; Crespy, D. Nanofibrous photocatalysts from electrospunnanocapsules. Nanotechnology2017,28, 405601. (IF=3.874) 5. Jiang, S.; Landfester, K.; Crespy, D. Control of the release of functional payloads from redox-responsive nanocapsules. RSC Adv. 2016,6, 104330-104337. (IF=3.361) 4. Jiang, S.; Lv, L.; Landfester, K.; Crespy, D. Dual-Responsive Multicompartment Nanofibers for Controlled Release of Payloads. RSC Adv. 2016,6, 43767-43770. (IF=3.361) 3. Jiang, S.; He, Z.; Li, Q.; Wang, J.; Wu, G.; Zhao, Y.; Kang, M. Effect of carbon fiber-graphene oxide multiscale reinforcements on the thermos-mechanical properties of polyurethane elastomer. Polym. Composite.2019,40, E953-E961. (IF=3.171) 2. Thiramanas, R.;+Jiang, S.;+ Simon, J.; Landfester, K.; Mailander, V. Silica Nanocapsules with Different Sizes and Physicochemical Properties as Suitable Nanocarriers for Uptake in T-cells. Int. J. Nanomedicine2020,15, 6069-6084. (IF=6.400, 共同一作) 1. He, Z.;+Jiang, S.;+ Li, Q.; Wang, J.; Zhao, Y.; Kang, M. Self-healing isocyanate microcapsules for efficient restoration of fracture damage of polyurethane and epoxy resins. J. Mater. Sci.2019,54, 8262. (IF=4.220, 共同一作)
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项目课题 | |||||
1. 中国海洋大学青年英才工程第一层次基金,纳米药物与纳米-生物界面研究,2021-2025,在研,主持。 2. 青岛海洋科学与技术国家实验室开放基金,2021-2025,在研,主持。 | |||||
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