王杨

王杨

博士

教授

博士生导师

科 室：

药物合成

电子邮箱：

wangyang@ouc.edu.cn

联系地址：

山东省青岛市香港东路23号中国海洋大学浮山校区海尔楼G609

研究方向：

1. 手性氮杂环的新型不对称催化合成方法研究

2. 氮杂环的手性合成方法在药物和活性天然产物合成中的应用

3. 新骨架类型氮杂环的合成及其生物活性挖掘

个人简介

教授，博士生导师，中国海洋大学“青年英才”工程第一层次人才，山东省泰山学者青年专家。近年来在Science, Chem. Soc. Rev.,Nat. Commun., J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Chin. Chem. Lett., JACS Au, Green Chem., Green Synth. Catal., Chin. J. Chem.,Org. Lett., Org. Chem. Front.等期刊发表SCI收录论文几十余篇，获得授权专利7项。主要研究领域为不对称催化合成氮杂环及其导向的天然产物合成和药物化学等。

教育背景

2008-2013

北京大学

有机化学

博士（导师：席振峰院士，张文雄教授）

2004-2008

中国农业大学

化学

学士（导师：施章杰教授）

工作经历

2025至今

中国海洋大学

教授

2019-2025

中国海洋大学

副教授

2017-2019

加拿大西蒙弗雷泽大学（SFU）

博士后

导师：Robert Britton

2013-2016

瑞士洛桑联邦理工学院（EPFL）

博士后

导师：JiepingZhu

学术兼职

担任Chin. Chem. Lett., Chin. J. Chem., Green Synth. Catal., Org. Lett., Org. Chem. Front., Chem. Commun., Chem. Eur. J., J. Org. Chem.等国际期刊审稿人。

荣誉奖励

1.     山东省“泰山学者”青年专家

2.     欧盟MARIE CURIE Fellowship

3.     陶氏化学全球可持续发展创新奖

研究进展

在现代药物研发的舞台上，氮杂环化合物因其在药物中的功能多样性和结构多样性而备受青睐。氮杂环的合成中，手性氮杂环的合成更具挑战，因为手性不同，药物的效果千差万别。选择性地合成手性分子的单一异构体是合成化学家和药物化学家长期追逐的梦想。王杨教授课题组致力于手性含氮杂环的不对称催化合成研究，近年来开展了系统而持续的研究工作，取得了一系列创新成果：1）通过合成方法的突破，实现反应化学、区域、立体选择性的可调可控，一步多键合成多手性中心结构多样的手性氮杂环；2）通过开发的不对称催化合成方法，高效地进行生物碱的合成；3）通过新颖合成方法所合成的高附加值新氮杂环化合物，进行先导化合物开发。

代表性成果

代表性论文 (*corresponding author)：

1.    Tengfei Xuan, Hongwei Zhao, Yichi Zhang, Jinyu Wang, Shuang Yang, Wei Wang,* and Yang Wang.*  Asymmetric catalytic construction of 1,1-diheteroquaternary tetrahydro-β-carbolines enables collective syntheses of polycyclic alkaloids. J. Am. Chem. Soc.2026, 148, 879.

2.    Xiaochen Tian, Hongli Wu, Yaoyu Shi, Xiaonan Cui, Ruochen Pang, Boqi Zhang, Rongrong Zhou, Ling Lu,* Yun-Fang Yang,* and Yang Wang.* Switchable reactivity of hydrazonoyl halides: enabling the discovery of potent hypoxia-inducible factor inhibitors. JACS Au2026, 6, 3164.

3.    Pengcheng Shaoa, Hang Chenga, Yanting Lia, and Yang Wang.* Asymmetric catalytic construction of β-carbolines via nucleophilic addition of silyl enol ethers with cyclic imines. Chin. Chem. Lett. 2026,DOI: https://doi.org/10.1016/j.cclet.2026.112795.

4.    Yidong Huang, HongLi Wu, Yuxin Tian, Lesong Li, Yun-Fang Yang,* and Yang Wang.*Asymmetric [1+4] cyclization of α-chloro hydrazones for the synthesis of pyrazoline-spirooxindoles. Chin. J. Chem.2026, 44, 1783.

5.    Pengcheng Shao, Hang Cheng, and Yang Wang.* Asymmetric catalytic dual-site functionalization of allyl bromides: construction of diverse heterocyclic frameworks. Chin. J. Chem.2026, 44, 111.

6.    Changhong Han, Hongli Wu, Tao Liu, Yun-Fang Yang,* and Yang Wang.* Regioselective α‑addition of deconjugated γ‑butenolides: synthesis of functionalized dihydroquinolinones. Org. Lett. 2026, 28, 3371.(Cover Page)

7.    Changhong Han, Xiaochen Tian, Hang Cheng, Yanting Li, Tao Liu, and Yang Wang.* Copper-catalyzed umpolung strategy of N-2,2,2-trifluoroethylisatin ketimines for the synthesis of spirobenzodiazepine oxindoles. Chem. Eur. J. 2026, 32, e00001.

8.    Yaoyu Shi, Yongxing Zhang, Xiang Xu, Yanting Li, Jingze Chen, and Yang Wang.* Asymmetric Synthesis of 2,3-Dihydrooxazoles via Acylaziridine Rearrangement of 2‑(1-Tosylalkyl)naphthols with N,O‑Hydroxylamines. J. Org. Chem.2026, 91, 10307.

9.     Yongxing Zhang, Xiaochen Tian, and Yang Wang.* Asymmetric Catalytic [3+3] annulations of unmodified Morita-Baylis-Hillman alcohols to construct diverse heterobicyclic [4.3.0] skeletons. JACS Au, 2025, 5, 5039.

10. Tengfei Xuan, Yuan Pan, Zhenyu Shi, and Yang Wang.* Organocatalytic asymmetric synthesis of oxazolines from N-acylimines. Chin. Chem. Lett.2025,36, 110352.

11. Tingting Zhang, Xiaochen Tian, Xin Shu, Honghan Li, Yihan Lu, and Yang Wang.*Indolylmethanols as C4 synthons for the asymmetric synthesis of indole-fused spiro compounds. Chin. J. Chem.2025, 43, 3483.

12. Tengfei Xuan, Xia Wang, and Yang Wang.*Asymmetric [3+2] cycloannulation of benzoxazinones for the synthesis of imidazo[5,1‑c]oxazinones. Org. Lett. 2025, 27, 3134.

13.  Xin Shu, Tingting Zhang, Yongxing Zhang, Kexin Tong, Shumin Wang, and Yang Wang.* Asymmetric construction of enantioenriched spiro gem-diamines via [3+3] annulation of α,β-unsaturated N-sulfonyl ketimines and 3-aminobenzofurans. Org. Chem. Front. 2025, 12, 3643.

14.  Xiaochen Tian, Tengfei Xuan, Jingkun Gao, Xinyu Zhang, Tao Liu, Fengbiao Luo, Ruochen Pang, Pengcheng Shao, Yun-Fang Yang,* and Yang Wang.* Catalytic enantioselective nitrone cycloadditions enabling collective syntheses of indole alkaloids. Nat. Commun. 2024, 15, 6429.

15.  Lesong Li, Tao Liu, Weiwu Ren, and Yang Wang.* Catalyst-free and atom-economical [4+3] cycloaddition of azadienes with cyclic azomethine imines for facile synthesis of 1,2,4-triazepines. Green Synth. Catal.2024, 5, 57.

16.  Shuting Zhang, Xinyu Zhang, Lesong Li, Zhenyu Shi, and Yang Wang.* Synthesis of pyridazino[4,5-b]indoles by [3+3] annulation of 2-alkenylindoles and hydrazonyl chlorides. Chem. Eur. J. 2024, 30, e202400278.

17.  Lesong Li, Congyang Li, Shuting Zhang, Xuerui Wang, Peng Fu, and Yang Wang.* Catalytic asymmetric synthesis of 3,4′-piperidinoyl spirooxindoles via [3+3] annulation of 3‑aminobenzofurans and isatin-derived enals. J. Org. Chem. 2024, 89, 5170.

18.  Lesong Li, Xia Wang, and Yang Wang.* Construction of spiro[pyrrolidine-azlactone] via [2+3] cycloaddition of alkylidene azlactone with trifluoromethylated imine J. Org. Chem. 2024, 89, 17824.

19.  Xinyu Zhang, Yuan Pan, Tao Liu, and Yang Wang.* Synthesis of 4‑aryl-1,3,4-benzotriazepinones from isatoic anhydrides and hydrazonyl chlorides. J. Org. Chem.2023, 88, 7504.

20.  Hao Dong, Yongxing Zhang, Xiaochen Tian, Ruochen Pang, Weiwu Ren, and Yang Wang.* Catalyst-free and oxidant-free tandem aza-Mannich/cyclization/aromatization of C,N-cyclic azomethine imines with enamides: facile synthesis of 5,6-dihydropyrazolo[5,1-a]isoquinolines. Green. Chem. 2022, 24, 5508. (Cover Page)

21.  Lesong Li, Tao Liu, Xiaoli Zhang, Xiaohan Hou, Hao Dong, Xiaoyang Li, Weiwu Ren, and Yang Wang.* Catalyst-free and atom-economical 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines: facile synthesis of isoquinoline-fused spirocycles. Green Synth. Catal.2022, 2, 69.

22.  Fengbiao Luo, Hao Dong, Weiwu Ren, and Yang Wang.*Organocatalytic asymmetric synthesis of tetrahydroquinolines from ortho-aminophenyl para-quinone methides. Org. Lett. 2022, 24, 7727.

23. Yuan Pan, Weiwu Ren, Zhanhao Zhang, Fengbiao Luo, Xiaohan Hou, Xiaoyang Li, Yun-Fang Yang,* and Yang Wang.* Tandem 1,6-addition/cyclopropanation/rearrangement reaction of vinylogous para-quinone methides with 3-chlorooxindoles: construction of vicinal quaternary carbon centers. Org. Chem. Front. 2022, 9, 3697.

24. Xiaochen Tian, Yongxing Zhang, Hao Dong, Weiwu Ren, and Yang Wang.* Asymmetric α‑regioselective [3+2] annulation of Morita−Baylis−Hillman carbonates: construction of three contiguous stereocenters with vicinal quaternary carbon centers. J. Org. Chem.2022, 87, 9593.

25. Xiaochen Tian, Yongxing Zhang, Weiwu Ren, and Yang Wang.* Synthesis of functionalized 3,2'-pyrrolidinyl spirooxindoles via domino 1,6-addition/annulation reactions of para-quinone methides and 3-chlorooxindoles. Org. Chem. Front. 2022, 9, 615. (Cover Page)

26. Michael Meanwell, Steven M. Silverman, Johannes Lehmann, Bharanishashank Adluri, Yang Wang, Ryan Cohen, Louis-Charles Campeau, Robert Britton.* A short de novo synthesis of nucleoside analogs. Science2020, 369, 725.

27. Yang Wang,* Wen-Xiong Zhang, Zhenfeng Xi. Carbodiimide-based synthesis of N-heterocycles: moving from two classical reactive sites to chemical bond breaking/forming reaction. Chem. Soc. Rev.2020,49, 5810.

28. Yang Wang, Qian Wang, Jieping Zhu.* Organocatalytic nucleophilic addition of hydrazones to imines: synthesis of enantioenriched vicinal diamines. Angew. Chem. Int. Ed. 2017, 56, 5612.

29. Yang Wang, Yue Chi, Wen-Xiong Zhang,* Zhenfeng Xi.* Regioselective ring expansion of 2,4-diiminoazetidines via cleavage of C–N and C(sp3)-H bonds: efficient construction of 2,3-dihydropyrimidinesulfonamides.J. Am. Chem. Soc. 2012, 134, 2926.

30.Yang Wang, Wen-Xiong Zhang,* Zitao Wang, Zhenfeng Xi.* Procedure-controlled selective synthesis of 5-acyl-2-iminothiazolines and their selenium and tellurium derivatives by convergent tandem annulation.Angew. Chem., Int. Ed. 2011, 50, 8122.

项目课题

1.     中国海洋大学“青年英才工程“基金，主持

2.     青岛海洋科学与技术国家实验室创新人才引进项目，主持

3.     山东省泰山学者青年专家项目，主持

4.     中国海洋大学优秀青年科技人才培育基金，主持

5.     山东省自然科学基金青年项目，主持

6.     国家自然科学基金青年项目，主持

7.     国家自然科学基金面上项目，主持

8.     浙江省功能分子精准合成重点实验室基金，主持

9.     山东省自然科学基金优秀青年项目，主持