张国建

作者:蔡超时间:2019-08-21

E:\溢出坚果云\work at OUC 2018\Guojian 证件照及复印件\GZ20211031修图.jpg

张国建

博士

教授

士生导师

科 室:

天然药物化学研究室

办公电话:

0532-82032971

电子邮箱

zhangguojian@ouc.edu.cn

联系地址:

山东省青岛市鱼山路5号中国海洋大学医药学院海洋馆205邮编:266003

研究方向:

1.海洋微生物活性天然产物分子的发现

2.微生物生物合成和代谢工程研究

个人简介

 

 

 

 

山东省泰山学者青年专家(2020),入选中国海洋大学青年英才工程20066月毕业于中国海洋大学药学专业,获得学士学位;20116月毕业于中国海洋大学药物化学专业,获得博士学位。20121月至20179月先后在纽约州立大学布法罗分校(Blaine Pfeifer 课题组)和俄克拉荷马大学(Robert Cichewicz课题组)从事博士后研究。Sci. Adv., Curr. Opin. Biotech., J. Nat. Prod., Biotechnol. Bioeng.等期刊发表SCI收录论文30余篇。主持国家自然科学基金面上(419761052020.1-2023.12),参与国家自然科学基金重大项目(819915222020.1-2024.12国家重点研发项目(2019YFC03125002019.08-2021.12)等课题。担任Curr. Opin. Biotech.杂志客座编辑和中国抗生素杂志青年编委,并担任ACS Synth. Biol., J. Nat. Prod., App. Microbial. Biotechnol.等二十余个期刊审稿工作主要研究方向包括:海洋环境来源微生物功能基因和代谢产物的潜能挖掘、活性次级代谢产物的发现;基于代谢工程和合成生物学方法改造和优化天然产物的生物合成途径,获得工程化菌株和结构新颖的活性分子。

教育背景

 

 

 

 

2006.09~2011.07

中国海洋大学

药物化学

博士

2002.09~2006.06

中国海洋大学

生物技术

学士

工作经历

 

 

 

 

2017.07~今

中国海洋大学 医药学院

副教授

 

2014.12~2016.12

俄克拉荷马大学

博士后

 

2012.01~2014.12

纽约州立大学布法罗分校

博士后

 

学术兼职

 

 

 

 

Curr. Opin. Biotech.杂志客座编辑和中国抗生素杂志青年编委,并担任ACS Synth. Biol., J. Nat. Prod., App. Microbial. Biotechnol.等二十余个期刊审稿工作

荣誉奖励

 

 

 

 

山东省泰山学者青年专家(2020

承担课程

 

 

 

 

药学分子生物学(本科生课程)

海洋微生物药物研究生课程)

高等分子生物学(研究生课程)

Marine Natural Products(国际研究生课程)

研究进展

 

 

 

 

基于基因组分析采掘结合现代天然产物化学研究方法开发海洋微生物代谢潜能,获得了联苯杂环类、特拉酸类、混源以及寡肽类等多种结构新颖的天然产物。上述结构在抗肿瘤、抗炎、抗感染等领域表现出了良好的应用潜力。

利用代谢工程、组合生物合成和异源表达技术改造和优化天然产物生物合成途径,获得工程化菌株和结构新颖的天然产物分子前期利用大肠杆菌宿主成功完成了红霉素、水杨酸糖苷衍生物等系列药物分子的异源表达。目前开展针对于莽草酸途径的代谢工程研究以及混源Alternarenes)、抗菌肽(Peptaibols)和多硫代二酮哌嗪(Penicisulfuranol)等活性分子的生物合成研究。

 

代表性成果

代表论文

 

 

 

 

1. Yimin Chang, Qian Che, Li Xing,Chuanteng Ma,Yaxin Han,Tianjiao Zhu, Blaine A. Pfeifer, Jixing Peng, Guojian Zhang* andDehai Li*. Antibacterial p-Terphenyls with rare 2,2'-bithiazole moiety isolated from marine-derived actinomycete Nocardiopsis sp. HDN154086. J. Nat. Prod.2021,84, 4, 1226–1231. (IF4.050)

2. Guoliang Zhou, Tianjiao Zhu, Qian Che, Guojian Zhang*, Dehai Li*. Structural diversity and biological activity of natural p-terphenyls. Marine Life Science & Technology 2021, DOI:10.1007/s42995-021-00117-8.

3. Chuanteng Ma, Kaijin Zhang, Xianyan Zhang, Guowei Liu, Tianjiao Zhu, Qian Che, Dehai Li and Guojian Zhang*.Heterologous expression and metabolic engineering tools for improving terpenoids production. Curr. Opin. Biotech.,2021, 69, 281-289. (IF9.740)

4. Ruonan Sun, Yanyan Feng, Hengyi Xu, Xuewen Hou, Tianjiao Zhu, Qian Che, Blaine Pfeifer, Guojian Zhang* and Dehai Li*. An Efficient Marker Recycling System for Sequential Gene Deletion in a Deep Sea-derived Fungus Acremonium sp.HDN16-126. Synth. Syst.Biotechnol.,2021, 6, 2, 127-133. (IF4.708)

5. Lu Wang, Xianyan Zhang, Kaijin Zhang, Xiaomin Zhang, Tianjiao Zhu, Qian Che, Guojian Zhang* and Dehai Li*. Overexpression of Global RegulatorbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicilliumrocae HDN-12-143. Front. Chem., 2020, online. DIO: 89/fchem.2020.00270. (IF5.221)

6. Lu Wang, Jieying Jiao, Dan Liu, Xiaomin Zhang, Jing Li, Qian Che, Tianjiao Zhu, Dehai Li* and Guojian Zhang*. Cytotoxic Meroterpenoids from the Sponge‐Associated Fungus Alternaria sp. JJY‐32. Chem. Biodivers., 2020, 17, e2000226. Front. (IF2.408)

7. Xueping Ge, Chunxiao Sun, Yanyan Feng, Lingzhi Wang, Jixing Peng, Qian Che, Qianquan Gu, Tianjiao Zhu, Dehai Li and Guojian Zhang*. Anthraquinone Derivatives from a Marine-Derived Fungus Sporendonemacasei HDN16-802. Mar. Drugs, 2019, 17:334.(IF5.118)

8. Tingting Zhao, Yimin Chang, Tianjiao Zhu, Jing Li, Qianqun Gu, Dehai Li, Qian Che* and Guojian Zhang*. α-Pyrone derivatives with cyto-protective activity from two TaklaMakan Desert Soil Derived Actinomycete Nocardiopsis Strains Recovered in Seawater Based Medium.Nat. Prod. Res., 2019, 33(17), 2498-2506.(IF2.861)

9. Chunxiao Sun, Shah Mudassir, Zhenzhen Zhang, Yanyan Feng, Yimin Chang, Qian Che, Qianqun Gu, Tianjiao Zhu, Guojian Zhang* and Dehai Li*. Secondary Metabolites from Deep-Sea Derived Microorganism. Curr. Med. Chem. 2019, DIO: 10.2174/0929867326666190618153950. (IF4.530)

10. Guihong Yu, Guangwei Wu, Zichao Sun, Xiaomin Zhang, Qian Che, Qianqun Gu, Tianjiao Zhu, Dehai Li and Guojian Zhang*. Cytotoxic tetrahydroxanthone dimers from the mangrove-associated fungus Aspergillus versicolor HDN1009, Mar. Drugs, 2018, 16:335. (IF5.118)

11. Lei Fang#, Guojian Zhang#*, Omar El-Halfawy, Eric D. Brown and Blaine. A. Pfeifer*. Broadened Glycosylation Patterning of Heterologously Produced Erythromycin. Biotechnol. Bioeng., 2018, 115, 2771-2777. (IF4.530)

12. Zhenzhen Zhang, Xueqian He, Guangwei Wu, Congcong Liu, Changjun Lu, Qianqun Gu, Qian Che, Tianjiao Zhu, Guojian Zhang,* and Dehai Li*. Aniline-tetramic Acids from the Deep-sea Derived Fungus Cladosporium sphaerospermum L3P3 Cultured with the HDAC Inhibitor SAHA. J. Nat. Prod. 2018, 81 (7), 1651–1657. (IF4.050)

13. Ruiquan Qi, Blaine A Pfeifer* and Guojian Zhang*, Engineering heterologous production of salicylate glucoside and glycosylated variants.Front. Microbiol., 2018, 9, 2441. (IF5.640)

14. Zhenzhen Zhang, Xueqian He, Qian Che,Guojian Zhang*, Tianjiao Zhu, Qianqun Gu and Dehai Li*. Sorbicillasins A-B and Scirpyrone K from a Deep-Sea-Derived Fungus, Phialocephala sp. FL30r. Mar. Drugs, 2018, 16 :245. (IF5.118)

15. Charles H Jones#, Guojian Zhang#, RoozbehNayerhoda, Marie Beitelshees, Andrew Hill, Pooya Rostami, Yi Li, Bruce A Davidson, Paul Knight, Blaine A Pfeifer. Comprehensive vaccine design for commensal disease progression. Sci. Adv., 2017, 3, e1701797. (#Co-first author). (IF14.136)

16. Guojian Zhang, Jing Li, Tianjiao Zhu, Qianqun Gu and Dehai Li. Advanced tools in marine natural drug discovery. Curr. Opin. Biotech. 2016, 43, 13-23. (IF9.740)

17. Guojian Zhang, Yi Li, Lei Fang and Blaine A. Pfeifer. Tailoring Pathway Modularity in the Biosynthesis of Erythromycin Analogues Heterologously Engineered in E. coli.Sci. Adv., 2015, 1, e1500077. (IF14.136)

18. Guojian Zhang, Guangwei Wu, Tianjiao Zhu, Tibor Kurtán, Attila Mándi, Jieying Jiao, Jing Li, Xin Qi, Qianqun Gu, and Dehai Li. Meroterpenoids with Diverse Ring Systems from the Sponge-Associated Fungus Alternaria sp. JJY-32. J. Nat. Prod., 2013, 76, 1946–1957. (IF4.050)

19. Xinying Yang#, Guojian Zhang#, Xuelian Tang, Jieying Jiao, Sung Yeon Kim, Joo Young Lee, Tianjiao Zhu, Dehai Li, Yong Gab Yun and Qianqun Gu. Toll-like Receptor 4/Nuclear Factor-κB Signaling Pathway is Involved in ACTG-toxin H-mediated Anti-inflammatory Effect. Mol. Cell. Biochem., 2013, 374, 29-36. (#Co-first author). (IF3.396)

20. Xueping Li#, Guojian Zhang#, Tianjiao Zhu, Dehai Li, Qianqun Gu. Strain and culture medium optimization for Production Enhancement of Prodiginines from Marine-derived Streptomycessp GQQ-10. J. Ocean Univ. China, 2012, 11, 361-365. (#Co-first author). (IF0.913)

21. Guojian Zhang, Shiwei Sun, Tianjiao Zhu, Zhenjian Lin, Jingyan Gu, Dehai Li and Qian-qun Gu. Antiviral Isoindolone Derivatives from an Endophytic Fungus Emericella sp. Associated with Aegicerascorniculatum.Phytochemistry,2011, 72, 1436-1442. (IF4.072)

22. Zhenjian Lin#,Guojian Zhang#, Tianjiao Zhu, Rui Liu, Hongjuan Wei, and Qianqun Gu. Bioactive Cytochalasins from Aspergillus flavipes, an Endophytic Fungus Associated with Mangrove Plant Acanthus ilicifolius. Helv. Chim. Acta., 2009, 92, 1538-1544. (#Co-first author). (IF2.164)

 

出版著作

 

 

 

 

参编英文专

1. Ruiquan Qi, Guojian Zhang, B.A. Pfeifer. In Engineering Escherichia coli for bacterial natural product production. Chaitan Khosla, Sean Brady, Jay Keasling, Eds; Comprehensive Natural Products III: Chemistry and Biology. Elsevier, 2019.

2. Lei Fang, Guojian Zhang, Blaine A Pfeifer. In Engineering of E. coli for Heterologous Expression of Secondary Metabolite Biosynthesis Pathways Recovered from Metagenomics Libraries; Trevor C. Charles, Mark R. Liles, Angela Sessitsch, Eds; Functional Metagenomics: Tools and Applications. Springer-Verlag London Ltd, 2017.

3. Guojian Zhang and Blaine A. Pfeifer. In Production of Therapeutic Products; Anne Osbourn, Rebecca Goss, Guy T. Carter, Eds; Natural Products: Discourse, Diversity, and Design; Wiley-Blackwell Ltd, 2014.

4. Yi Li, Guojian Zhang, Blaine A. Pfeifer. In Current and Emerging Options for Taxol Production; Jens Schrader, Jörg Bohlmann, Eds; Biotechnology of Isoprenoids. Springer-Verlag London Ltd, 2014.

专利

 

 

 

 

 

项目课题

1. 2020.01-2023.12 国家自然科学基金面上项目(41976105),主持,74.4万元。

2. 2021.01-2025.12 山东省泰山学者青年专家项目(tsqn202103153),主持50.0万元

3. 2020.01-2024.12国家自然科学基金重大项目(81991522),参与,50.0万元

4. 2019.08-2021.12 国家重点研发项目(2019YFC0312500,参与,主持子任务,110.0万元

5. 2017.07-2022.07中国海洋大学青年英才工程项目启动基金,主持15.0万元

6. 2019.06-2021.06  海洋科学与技术国家试点实验室开放基金,参与7.5万元

 






 

 

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