姜帅

姜 帅

博士

教 授

博士生导师

科 室：

药剂学实验室

电子邮箱：

jiangshuai@ouc.edu.cn

研究方向：

1. 纳米-生物相互作用：作用机制、生物效应与调控策略

2. 纳米药物蛋白冠的分析检测技术及其生物效应研究

3. 生物大分子递送体系及其在药物递送和合成生物学中的应用

个人简介

教授，博士生导师。2016年于中国科学院获博士学位，先后于德国马普高分子所进行博士联培、博士后研究、担任课题组长。2021年加入海大医药学院，从事纳米药物递送系统与纳米-生物界面作用的研究工作。主持国自然青年基金、山东省优秀青年基金（海外）、“泰山学者”青年专家等项目，担任海大-逢时海洋磷脂研究中心主任。发表论文80余篇，其中以第一或通讯作者在Chem. Soc. Rev.、Acc. Chem. Res.、Sci. Adv.、Sci. Bull.、Angew. Chem.（7）、Adv. Mater.、Adv. Funct. Mater.、Adv. Sci.（2）、ACS Nano（2）、Nano Lett.（3）、JCR（2）等期刊发表论文50余篇，引用3000余次。

Google Scholar: https://scholar.google.de/citations?user=QU1qNosAAAAJ&hl=en

Researchgate: https://www.researchgate.net/profile/Shuai-Jiang-10

教育背景

2013.12~2015.11

德国马普学会高分子研究所

高分子物理化学

博士联培

2011.09~2016.06

中国科学院大学

山西煤炭化学研究所

工业催化

硕博连读

2007.09~2011.06

烟台大学

化学工程与工艺

学士

工作经历

2021.05~至今

中国海洋大学医药学院

教授

2019.09~2021.04

德国马普学会高分子所

课题组长

2016.08~2019.08

德国马普学会高分子所

博士后

研究进展

纳米药物靶向递释系统是一种极具开发潜力的药物递送策略，其通过改变药物的代谢动力学和组织分布，提高对肿瘤组织的特异性作用并同时降低药物对正常组织的毒性，在肿瘤治疗等领域得到了广泛的重视和发展。针对现阶段抗肿瘤纳米药物临床转化率低的瓶颈问题，本课题组从高效、智能药物递送纳米载体和纳米反应器的开发和纳米-血液蛋白相互作用两方面开展研究。基于胶体化学和界面聚合，开发了纳米乳液原位包覆技术，针对特定药物的具体性质（如亲疏水性、生物活性、分子尺寸、释药需求等），发展出一系列特异性纳米胶囊药物递释载体和酶级联纳米反应器；结合材料表面修饰与表征、蛋白质组学和细胞、动物实验，建立了纳米材料-血液蛋白相互作用的研究方法学，揭示了纳米药物与血液蛋白吸附行为的作用机制、生物效应及调控方法，为全面、深入认识纳米药物的体内命运、推动抗肿瘤纳米药物的临床转化提供了重要研究基础。

代表性成果

代表性论文(*通讯作者；+共同一作)

1.  S. Jiang, J.F. Zhang,* et al. Nano-bio interactions in nanomedicine: protein corona-mediated immune  clearance and surface engineering strategies. Sci. Bull. 2026, doi: 10.1016/j.scib.2026.08.062.

2. Y. Yu,+S. Jiang,* et al. Incorporation of Novel Synthetic Glycolipids in Liposomal Nanoparticles Affects Opsonization and In Vivo Clearance. Angew. Chem. 2026, 138, e20837.

3.    F. Fu, S. Jiang,* et al. Cholesterol-Mediated Protein Corona Controls In Vivo Clearance and Selective Organ Distribution of Liposomes. ACS Nano 2026, 20, 23345.

4.    X. Li,+S. Jiang,* et al. Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers. Adv. Sci. 2026,e77000.

5.    J. Ding,+S. Jiang,* et al.Serum Lipids Remodel the Biomolecular Corona to Direct Nanoparticle Biodistribution. Nano Lett. 2026, doi: 10.1021/acs.nanolett.6c01852.

6.    W. Yang,+S. Jiang,* et al. Beyond the liver and deeper in the liver: Sub-organ level analysis of in vivo sequestration mechanism of silica nanocapsules. J. Control. Release 2026, 395, 114948.

7.    T, He,+ S. Jiang,* et al. Macrophage Phenotype-Dependent Protein Corona Formation Governs Ligand Accessibility and Immune Clearance of Biomimetic Nanoparticles. Small 2026, 22, e14389.

8.    T. He, S. Jiang,* et al. Protein Corona Reprograms Hepatic Clearance Pathways of Biomimetic Nanoparticles via Ligand Masking and Differential Protein Enrichment. Small2026, 22, e73301.

9.   Q. Wang,+S. Jiang,* et al. Chitosan thermosensitive hydrogel-based sustained-release system of Netrin-1 overexpressing macrophage exosomes: synergistic enhancement of angiogenesis and nerve regeneration. NPG Asia Materials 2026, 18, 25.

10.  W. Han,+S. Jiang,* et al. Pathophysiological Protein Corona Governs the Biological Fate of Nanoparticles. ACS Appl. Mater. Interfaces 2026, 18, 21500.

11.  T. He, S. Jiang,* et al. Single-Particle Analysis Reveals Heterogeneity in Membrane Coating. Small Methods 2026, 10, e02352.

12.  Z. Wang, S. Jiang,* et al. Integrating Incompatible Tandem Photobiocatalysis in Artificial Cells Enables Metabolic Modulation of Natural Cells, Sci. Adv.2025, 11, eadu4828.

13. W. Han, S. Jiang,* et al. Self-Sustained Biophotocatalytic Nano-Organelle Reactors with Programmable DNA Switches for Combating Tumor Metastasis. Adv. Mater.2025, 37, 2415030.

14.  F. Fu,+S. Jiang,* et al. Engineering Artificial Mitochondria with Self-Amplifying Proton Generation for Autonomous Energy Supply and Metabolic Coupling in Artificial Cells, Angew. Chem. 2025, e202514980.

15.  Y. Ge,+S. Jiang,* et al. Physiological pH Transition‐Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles. Adv. Sci. 2025, e02788.

16.  Y. Qiu, S. Jiang,* et al. The Distribution of Complement Proteins in Soft and Hard Coronas Impacts Macrophage Uptake of Nanoparticles. Adv. Healthc. Mater.2025, 15, e03534.

17.  F. Fu, S. Jiang,* et al. In situ characterization techniques of protein corona around nanomaterials. Chem. Soc. Rev.2024,53, 10827.

18.  Y. Niu, S. Jiang,* et al. In Situ Measurement of Nanoparticle–Blood Protein Adsorption and Its Heterogeneity with Single-Nanoparticle Resolution via Dual Fluorescence Quantification. Nano Lett.2024, 24, 9202.

19.  R. Wang, S. Jiang,* et al. Liposomal Enzyme Nanoreactors based on Nanoconfinement for Efficient Anti-Tumor Therapy. Angew. Chem. 2023, 62, e202308761.

20.  J. Gonçalves, S. Jiang,* et al. Confining the Sol-Gel Reaction at the Water/Oil Interface: Creating Compartmentalized Enzymatic Nano-Organelles for Artificial Cells. Angew. Chem. 2023, 62, e202216966.

21. M. Prawatborisut, S. Jiang,*et al. Modulating Protein Corona and Materials-Cell Interactions with Temperature Responsive Materials. Adv. Funct. Mater.2022, 32, 2106353.

22. S. Jiang, K. Landfester,* et al. Synthetic Silica Nano-Organelles for Regulation of Cascade Reactions in Multi-Compartmentalized Systems. Angew. Chem. 2021, 133, 2.

23. M. Li, S.Jiang,* et al. Brush Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime. Nano Lett. 2021, 21, 1591.

24.  M. Li, S. Jiang,* et al. Encapsulation of polyprodrugs enables an efficient and controlled release of dexamethasone. Nanoscale Horiz. 2021, 6, 791.

25.  S. Jiang, K. Landfester,* et al. Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem ROS Generation.Angew. Chem.2020, 59, 2.

26.  W. Huang,+ N. Huber,+S. Jiang,+ K. Zhang,* et al. Covalent triazine framework nanoparticles via size-controllable confinement synthesis for enhanced visible light photoredox catalysis. Angew. Chem.2020, 59, 18368.

27.  S. Jiang, K. Landfester,* et al. Controlling protein interactions in blood for effective liver immunosuppressive therapy by silica nanocapsules.Nanoscale2020, 12, 2626.

28.  S. Jiang, K. Landfester,* et al. Versatile Preparation of Silica Nanocapsules for Biomedical Applications. Part. Part. Syst. Char.2020, 1900484.

29.  R. Thiramanas,+S. Jiang,+ V. Mailander,* et al. Silica Nanocapsules with Different Sizes and Physicochemical Properties as Suitable Nanocarriers for Uptake in T-cells. Int. J. Nanomedicine2020, 15, 6069.

30.  S. Jiang, K. Landfester,* et al. One-Step Preparation of Fuel-Containing Anisotropic Nanocapsules with Stimuli-Regulated Propulsion. ACS Nano2019, 14, 498.

31.  S. Jiang, Q. Li,* et al. Effect of carbon fiber-graphene oxide multiscale reinforcements on the thermos-mechanical properties of polyurethane elastomer. Polym. Composite2019, 40, E953.

32.  Z. He,+S. Jiang,+ Q. Li,* et al. Self-healing isocyanate microcapsules for efficient restoration of fracture damage of polyurethane and epoxy resins. J. Mater. Sci.2019, 54, 8262.

33.  S. Jiang, K. Landfester,* et al. Visible light active nanofibrous membrane for antibacterial wound dressing. NanoscaleHoriz.2018, 3, 439.

34.  S. Jiang, D. Crespy,* et al. The structure of fibers produced by colloid-electrospinning depends on the aggregation state of particles in the electrospinning feed. Polymer2017, 127, 101.

35.  S. Jiang, D. Crespy,* et al. Nanofibrous photocatalysts from electrospun nanocapsules. Nanotechnology 2017, 28, 405601.

36.  S. Jiang, D. Crespy,* et al. Nanocontainers in and onto Nanofibers. Acc. Chem. Res.2016, 49, 816.

37.  S. Jiang, Q. Li,* et al. Multiscale graphene oxide-carbon fiber reinforcements for advanced polyurethane composites. Compos. Part A2016,87, 1.

38.  S. Jiang, D. Crespy,* et al. Efficient Nanofibrous Membranes for Antibacterial Wound Dressing and UV Protection. ACS Appl. Mater. Interfaces2016, 8, 29915.

39.  S. Jiang, D. Crespy,* et al. Tailoring nanoarchitectonics to control the release profile of payloads. Nanoscale2016, 8, 11511.

40.  S. Jiang, D. Crespy,* et al. Directed Assembly of Soft Anisotropic Nanoparticles by Colloid Electrospinning. Macromol. Rapid Commun.2016,37, 1598.

41.  S. Jiang, D. Crespy,* et al. Control of the release of functional payloads from redox-responsive nanocapsules. RSC Adv.2016,6, 104330.

42.  S. Jiang, D. Crespy,* et al. Dual-Responsive Multicompartment Nanofibers for Controlled Release of Payloads. RSC Adv.2016,6, 43767.

43.  S. Jiang, Q. Li,* et al. Effect of surface silanization of carbon fiber on mechanical properties of carbon fiber reinforced polyurethane composites. Compos. Sci. Technol.2015, 110, 87.

项目课题

1.     国家自然科学基金青年基金，2023-2025，主持。

2.     山东省“泰山学者”青年专家，2026-2029，主持。

3.     山东省重点研发子课题，2025-2027，主持。

4.     山东省优秀青年科学基金项目（海外），2022-2025，在研，主持。

5.     中国海洋大学青年英才工程第一层次基金，2021-2025，在研，主持。

6.     青岛海洋科学与技术国家实验室开放基金，2021-2025，在研，主持。

7.     胶类中药联合创新中心项目，2024-2026，在研，主持。

8.     海大-逢时海洋磷脂联合研究中心项目，2026-2035，在研，主持。