范道庆 | 博士 | 副教授 | 硕士生导师 | ||
科 室: | 药物分析实验室 | ||||
办公电话: | dqfan93@163.com | 邮箱: | fdq9688@ouc.edu.cn | ||
联系地址: | 青岛市鱼山路5号,中国海洋大学医药学院海洋馆235 | ||||
研究方向: | 1. 智能分子逻辑器件的构筑及其生物医学应用 2. 抗肿瘤药物的高灵敏分析检测 3. 基于DNA纳米技术的生物传感器 4. 纳米酶催化及其药物分析和生物应用 | ||||
个人简介 |
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2013年进入中科院长春应化所电分析化学国家重点实验室硕博连读,师从汪尔康(中科院院士)和董绍俊(TWAS,第三世界科学院院士)研究员,主要从事基于分子逻辑器件和DNA纳米技术的生化传感和药物分析新方法、纳米酶催化及其药物分析和生物应用等方面的研究。2019年~2020年,于以色列耶路撒冷希伯来大学Itamar Willner教授(欧洲、德国、以色列科学院院士)课题组进行博士后研究。 2021年3月作为独立PI加入中国海洋大学医药学院开展研究工作,入选中国海洋大学“青年英才工程”。近5年在Advanced Science, ACS Nano, Materials Horizons (2), Chemical Science (4, RSC化学旗舰刊),AnalyticalChemistry, Biosensors & Bioelectronics, Advanced Materials, ACS Applied Materials & Interfaces, Nano Research, Chemical Communications等国内外著名杂志发表SCI论文近30篇,其中第一/共同第一作者论文19篇,IF>9的13篇,IF>10的6篇。根据Google Scholar统计,当前H指数18,被引用近800次。曾获“中国科学院院长优秀奖”等荣誉称号。 | |||||
教育背景 |
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2013年~2019年 | 中国科学院长春应用化学研究所 | 分析化学(硕博连读) | 博士 | ||
2009年~2013年 | 山东师范大学 | 化学 | 学士 | ||
工作经历 |
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2021.3~至今 | 中国海洋大学 医药学院 | 副教授 |
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2019年~2020年 | 以色列耶路撒冷希伯来大学 | 博士后 |
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学术兼职 |
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担任Chemical Science, Nucleic Acids Research, Analytical Chemistry, Chemical Communications等杂志审稿人。 | |||||
研究概况 |
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利用功能性核酸的多元化性质和DNA纳米技术,以氧化石墨烯、DNA纳米簇等多功能的纳米材料和荧光、比色染料等组成的复合体系作为独特的光学信号源,设计了一系列低成本高效的DNA智能逻辑器件和生物传感器。此外,在国际上率先创新性的提出了DNA“相反逻辑对”的概念,极大地推动了分子逻辑运算体系的发展。这些DNA逻辑器件不仅在生物分子信息处理中扮演着重要角色,而且为基于布尔逻辑运算的智能生物传感器、药物分析检测新器件的构筑打下了坚实的基础。 | |||||
代表性成果 | |||||
代表性论文 |
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1. DaoqingFan,*JunWang, Jiawen Han, Erkang Wang and Shaojun Dong*, Engineering DNA Logic Systems with Non-canonical DNA-nanostructures: Basic principles, Recent Developments and Bio-applications. Science China Chemistry, 2021, Just Accepted.(IF=9.445,一区TOP) 2. Daoqing Fan, Juan Wang, Erkang Wang* and Shaojun Dong*, Propelling DNA Computing with Materials’ Power: Recent Advancements in Innovative DNA Logic Computing Systems and Smart Bio-Applications. Advanced Science, 2020, 2001766.(IF=16.806,一区TOP) (被微信学术公众号AdvancedScienceNews和 材料人 相继报道) https://mp.weixin.qq.com/s/aGCOcTt6502dIXVlSksPIA,AdvancedScienceNews. https://mp.weixin.qq.com/s/pMgOKfMcAJ8vmgBVvishLQ, 材料人。 3. ZhixinZhou,#Daoqing Fan,# and Itamar Willner*, Modeling Gene Expression Instability by Programmed and Switchable Polymerization/Nicking DNA Nanomachineries. ACS Nano., 2020, 14, 5046-5052. (co-first author, IF=15.881) 4. Daoqing Fan, Erkang Wang* and Shaojun Dong*, Upconversion chameleon driven DNA computing: the DNA-unlocked inner-filter-effect (DU-IFE) for operating a multicolor upconversion luminescent DNA logic library and Its biosensing application. Materials Horizons, 2019, 6, 375-384.(IF=13.266,一区TOP)(入选该杂志Biosensors专辑) 5. Daoqing Fan, Erkang Wang and Shaojun Dong*, An intelligent universal system yields double results with half the effort for engineering a DNA ‘‘Contrary Logic Pairs’’ library and various DNA combinatorial logic circuits. Materials Horizons, 2017, 4, 924-931.(IF=13.266,一区TOP) 6. Daoqing Fan, Qingfeng Zhai, Weijun Zhou, Xiaoqing Zhu, Erkang Wang and Shaojun Dong*, A label-free colorimetric aptasensor for simple, sensitive and selective detection of Pt (II) based on platinum (II)-oligonucleotide coordination induced gold nanoparticles aggregation. Biosensors& Bioelectronics, 2016, 85, 771-776.(IF=10.618,一区TOP) 7. Qingfeng Zhai,#Daoqing Fan,# Xiaowei Zhang, Jing Li* and Erkang Wang*, Dual-electrochromic bipolar electrode-based universal platform for the construction of various visual advanced logic devices. NPG Asia Materials,2017, 9, e421. (co-first author, IF=10.481) 8. Daoqing Fan, Juan Wang, Erkang Wang* and Shaojun Dong*, Janus-inspired Amphichromatic System that Kills Two Birds with One Stone for Operating a “DNA Janus Logic Pair” (DJLP) Library. Chemical Science, 2019, 10, 7290-7298.(IF=9.825,RSC化学旗舰刊,一区TOP) 9. Daoqing Fan, Yongchao Fan, Erkang Wang and Shaojun Dong*, A simple, label-free, electrochemical DNA parity generator/checker for error detection during data transmission based on “aptamer-nanoclaw”-modulated protein steric hindrance. Chemical Science, 2018, 9, 6981-6987.(IF=9.825,RSC化学旗舰刊,一区TOP) 10. Daoqing Fan, Erkang Wang and Shaojun Dong*, A DNA-based parity generator/checker for error detection through data transmission with visual readout and an output-correction function. Chemical Science, 2017, 8, 1888-1895.(IF=9.825,RSC化学旗舰刊,一区TOP) 11. Daoqing Fan,Kun Wang, Jinbo Zhu, Yong Xia, Yanchao Han, Yaqing Liu*, Erkang Wang*, DNA-based visual majority logic gate with one-vote veto function. Chemical Science, 2015,6, 1973-1978. (IF=9.825,RSC化学旗舰刊,一区TOP) 12. Daoqing Fan, Changshuai Shang, Wenling Gu, Erkang Wang and Shaojun Dong*, Introducing ratiometric fluorescence to MnO2 nanosheet-based biosensing: a simple, label-free ratiometric fluorescent sensor programmed by cascade logic circuit for ultrasensitive GSH detection. ACS Applied Materials& Interfaces, 2017, 9, 25870-25877.(IF=9.229,一区TOP)(被引90余次) 13. Daoqing Fan, Erkang Wang and Shaojun Dong*, Exploiting polydopamine nanospheres to DNA computing: a simple, enzyme-free and G‑quadruplex-free DNA parity generator/checker for error detection during data transmission. ACSApplied Materials& Interfaces, 2017, 9, 1322-1330.(IF=9.229,一区TOP) 14. Daoqing Fan, Erkang Wang and Shaojun Dong*, Simple, fast, label-free, and nanoquencher-free system for operating multivalued DNA logic gates using polythymine templated CuNPs as signal reporters, Nano Research, 2017, 10 (8): 2560-2569.(IF=8.898,一区TOP) 15. Daoqing Fan, Xiaoqing Zhu, Qingfeng Zhai, Erkang Wang, and Shaojun Dong*, Polydopamine nanotubes as an effective fluorescent quencher for highly sensitive and selective detection of biomolecules assisted with Exonuclease III amplification. Analytical Chemistry, 2016, 88, 9158−9165.(IF=6.986,一区TOP) 16. Daoqing Fan, Jinbo Zhu, Yaqing Liu, Erkang Wang and Shaojun Dong, Label-free and enzyme-free platform for the construction of advanced DNA logic devices based on the assembly of graphene oxide and DNA-templated AgNCs. Nanoscale, 2016, 8, 3834-3840.(IF=7.79) 17. Daoqing Fan, Jinbo Zhu, Qingfeng Zhai, Erkang Wang and Shaojun Dong, Cascade DNA logic device programmed ratiometric DNA analysis and logic devices based on a fluorescent dual-signal probe of a G-quadruplex DNAzyme. Chemical Communications, 2016, 52, 3766-3769. (IF=6.222) 18. Daoqing Fan, Changtong Wu, Kun Wang, Xiaoxiao Gu, Yaqing Liu and Erkang Wang, A polydopamine nanosphere based highly sensitive and selective aptamer cytosensor with enzyme amplification. Chemical Communications, 2016, 52, 406-409. (IF=6.222) 出版著作 Daoqing Fan, Erkang Wang and Shaojun Dong, DNA‐ and RNA‐Based Computing Systems, Wiley, 2020. (Invited Book Chapter) | |||||
项目课题 | |||||
1. 中国海洋大学“青年英才工程”启动经费,2021-2025,在研,主持。 2. 青岛海洋科学与技术国家实验室开放基金,2021-2025,在研,主持。 | |||||
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