韩璐

韩璐

博士

教授

博士生导师

科 室：

药剂学实验室

办公电话：

电子邮箱：

hanlu@ouc.edu.cn

联系地址：

山东省青岛市鱼山路5号中国海洋大学医药学院, 邮编266003

研究方向：

1. 海洋生物医用材料

2. 用于组织再生与修复材料的仿贻贝粘附水凝胶

3. 仿生智能药物递送载体

个人简介

于2020年加入医药学院开展独立研究，教授，博导，入选斯坦福大学-Elsevier"全球前2%顶尖科学家"（2022-2024连续三年）、获评Materials Horizons新锐科学家、担任山东省高校"青创科技计划"创新团队负责人。研究工作聚焦仿生组织粘附性水凝胶与智能药物递送系统研究领域，开发了一系列基于海洋生物资源的新型功能材料，通过精确调控材料表界面性能，在组织精准修复、可控药物释放及抗菌抗炎抗肿瘤协同治疗等方面取得重要成果。已在Advanced Materials、Matter、ACS Nano、Angewandte Chemie International Edition、Advanced Functional Materials等国际权威期刊发表论文40余篇，其中10篇入选ESI高被引论文，总被引3800余次，H指数28。主持国家自然科学基金青年项目、山东省优秀青年基金等科研项目。指导学生团队荣获全国"互联网+"大学生创新创业大赛校级一等奖、第十一届全国大学生医学创新大赛暨"一带一路"国际竞赛省级三等奖等荣誉。

Google scholar:https://scholar.google.com/citations?user=maP4dcwAAAAJ&hl=en

ResearchGate:https://www.researchgate.net/profile/Lu_Han95

教育背景

2012.09 ~ 2017.06

西南交通大学

材料科学与工程

博士

2008.09 ~ 2012.06

西南交通大学

生物医学工程

学士

工作经历

2020.04~今

中国海洋大学

教授

2017.09~2019.12

德国莱布尼兹新材料研究所

博士后

2015.06~2015.08

香港中文大学

研究助理

学术兼职

• 担任Biomaterials Translational及Chinese Chemical Letters (CCL)期刊青年编委

•担任多个英文学术期刊（Nature Communications、Advanced Materials、Research等）审稿人

•中国生物材料学会高级会员、国际华人骨研学会(ICMRS)终身会员、山东省青年医务工作者协会药物药理学分会委员、山东省药学会制药工程专业委员会委员员、青岛市药学会药剂学专业委员会委员、青岛市药学会海洋药物专业委员会委员。

研究进展

组织修复材料的生物功能性和界面结合性问题是影响其临床应用的关键瓶颈，涉及材料、化学、医学等多学科交叉，而传统的组织修复材料普遍存在湿态组织粘附/整合性弱、生物功能性不足两大难题。团队基于海洋生物材料特色，聚焦仿生功能化生物材料与组织修复再生这一核心科学问题，仿生海洋贻贝的多尺度粘附机制，形成了“界面-功能-调控”的新型仿生生物材料体系。包括借鉴贻贝在水环境中稳定粘附的分子机制，开发新型仿贻贝组织粘附水凝胶，突破湿组织表面粘附的关键技术难题；提出酚醌氧化还原介导的自组装机制，构建具有分子识别和细胞粘附功能的智能递送载体提高靶向细胞药物递送效率；进一步利用粘附介导外场刺激驱动微环境重塑策略，设计具有仿生智能水凝胶，并耦合光/电场等物理刺激调控细胞行为，为复杂组织再生提供解决方案。

代表性成果

代表性论文 (#equal contribution; *corresponding author)：

1.     Yuping Jiang, Yufeng Li, Kexuan Wang, Xiaomin Feng, Weiqing Zhao, Chensong Huang, Jianfeng Zhou, Zhilu Yang, Chuanbin Shen, Lu Han*, NIR-driven nanomotors integrating with platelet-thylakoid hybrid membranes for synchronized thrombolysis and vascular remodeling, Advanced Materials 2025, e11733 (入选Nanowerk Spotlight Series)

2.     Di Liu, Jingxian Gao, Xueling Wu, Xinxin Hao, Wenxiu Hu, Lu Han*, Conductive microneedles loaded with polyphenol-engineered exosomes reshape diabetic neurovascular niches for chronic wound healing, Advanced Science 2025, e07974.

3.     Haohua Ma, Xiaozhuang Li, Xiaomin Feng, Yufeng Li, Di Liu,Lu Han*, Mesoporous silica-based nanomotors loaded with rapamycin for synergistic treatment of rheumatoid arthritis, ACS Nano2025, 19, 22914–22930.

4.     Yuping Jiang, Xiaomin Feng, Xin Qiao, Yufeng Li, Xiaozhuang Li, Jinguang Yang, Lu Han*, Plant-inspired visible-light-driven bioenergetic hydrogels for chronic wound healing, Bioactive Materials 2024, 41, 523-536.

5.     Xiao Wang, Xiaotong Sun, Donglin Gan, Manon Soubrier, Hsin-Yin Chiang, Liwei Yan, Yingqi Li, Junjun Li, Shuang Yu, Yang Xia, Kefeng Wang, Qiaozhen Qin, Xiaoxia Jiang*, Lu Han*, Taisong Pan*, Chaoming Xie*, Xiong Lu*, Bioadhesive and conductive hydrogel-integrated brain-machine interfaces for conformal and immune-evasive contact with brain tissue, Matter 2022, 5, 1204-1223. (ESI 高被引,被《MIT科技评论》以封面头条形式报道)

6.     Lingxiao Meng, Wanli Ma, Yuping Jiang, Xiaozhuang Li, Minglei Zhang, Rundong Yuan, Yaqiu Fu, Haohua Ma, Xiong Lu, Lu Han*, Hongrui Liu*, Minqi Li*, Bone‐targeting and multishelled oral eldecalcitol nanoparticles improve osteoporosis by reconstruction of osteogenic‐osteoclastic homeostasis,Advanced Functional Materials 2024, 2404549.

7.     Qiqi Zhang, Di Liu, Jingxian Gao, Xueling Wu, Wenxiu Hu, Lu Han*, Surface-engineered hydrophobic hydrogels via cholesterol micelle rearrangement for robust wet adhesion and oral mucositis therapy, Materials Today Bio 2025, 34, 102126.

8.     Wenxiu Hu, Di Liu, Jingxian Gao, Xinyue Zhang, Qiqi Zhang, Lu Han*, Bioinspired polyphenols nanoparticles-assembled microneedles integrating antioxidant defense with immune-melanogenic reprogramming for precision vitiligo phototherapy, Chinese Chemical Letters 2025.

9.     Xinyue Zhang, Shuyun Liu, Rui Xin, Wenxiu Hu, Qiqi Zhang, Qian Lu*, Lu Han*, Reactive oxygen species-responsive prodrug nanomicelle-functionalized Lactobacillus rhamnosus probiotics for amplified therapy of ulcerative colitis, Materials Horizons2025,12, 5749-5761.（入选EmergingInvestigators Series）

10.Yujia Zheng, Shengxi Jiang, Qiaoqi Zheng, Yanan Jiang, Siwen Fang, Wei Zhang, Chuanbin Shen, Chaoming Xie*, Xiong Lu*,Lu Han*,Rapid hemostatic and bio-adhesive polyphenol powders with physiological extreme condition-tolerance for noncompressible wound healing,Chemical Engineering Journal2025, 511, 162231, 158757.

11.Yuping Jiang, Yufeng Li, Kexuan Wang, Xiaomin Feng, Lu Han*, Hai Yang*, MnO2-based bioresponsive nanoplatform synergizing mitochondrial metabolism modulation for amplified phototherapy and chemodynamic therapy of melanoma, Chemical Engineering Journal2025, 504, 158757.

12.Peier Chen, Wei Zhang, Xianglin Fan, Xu Shi, Yanan Jiang, Liwei Yan, Hekai Li, Chunming Wang, Lu Han*, Xiong Lu*, Caiwen Ou*, A polyphenol-derived redox-active and conductive nanoparticle-reinforced hydrogel with wet adhesiveness for myocardial infarction repair by simultaneously stimulating anti-inflammation and calcium homeostasis pathways, Nano Today2024, 55, 102157. (ESI 高被引文章)

13.Liwei Yan, Changming Zhao, Yan Wang, Qiaozhen Qin, Zhiding Liu, Yuelin Hu, Zhenhua Xu, Kefeng Wang, Xiaoxia Jiang*, Lu Han*, Xiong Lu*, Adhesive and conductive hydrogel-based therapy simultaneously targeting neuroinflammation and neurofunctional damage after brain injury, Nano Today2023, 51, 101934.

14.Yanan Jiang, Xin Zhang, Wei Zhang, Menghao Wang, Liwei Yan, Kefeng Wang, Lu Han*, Xiong Lu*, Infant skin friendly adhesive hydrogel patch activated at body temperature for bioelectronics securing and diabetic wound healing, ACS Nano2022, 16, 6, 8662-8676. (ESI 高被引文章)

15.Donglin Gan, Yanan Jiang, Yuelin Hu, Xiao Wang, Qiguang Wang, Kefeng Wang, Chaoming Xie, Lu Han*, Xiong Lu*, Mussel-inspired extracellular matrix-mimicking hydrogel scaffold with high cell affinity and immunomodulation ability for growth factor-free cartilage regeneration,Journal of Orthopaedic Translation 2022, 33, 120-131. (ESI 高被引文章, 入选爱思唯尔中国金色开放获取高下载论文)

16.Yanan Jiang#, Ximan Pan#, Mengyu Yao#, Lu Han*, Xin Zhang, Zhanrong Jia, Jie Weng, Wenxiang Chen, Liming Fang*, Xiaolan Wang, Yu Zhang*, Ranxi Duan, Fuzeng Ren, Kefeng Wang, Xian Chen, Xiong Lu*, Bioinspired adhesive and tumor microenvironment responsive nanoMOFs assembled 3D printed scaffold for anti-tumor therapy and bone regeneration, Nano Today 2021, 39, 101182. (ESI 高被引文章)

17.Lu Han, Yijun Zheng, Hao Luo, Jun Feng, Roxanne Engstler, Lulu Xue, Guangyin Jing*, Xu Deng*, Aránzazu del Campo, Jiaxi Cui*, Macroscopic self-evolution of dynamic hydrogels to create hollow interiors, Angewandte Chemie International Edition2020, 59, 5611-5615.

18.Lu Han,Kezhi Liu, Menghao Wang, Kefeng Wang, Liming Fang, Haiting Chen, Jie Zhou, Xiong Lu*, Mussel-inspired adhesive and conductive hydrogel with long-lasting moisture and extreme temperature tolerance, Advanced Functional Materials 2018, 28, 1704195. (ESI 高被引文章)

19.Lu Han, Xiong Lu*, Kezhi Liu, Kefeng Wang, Liming Fang, Lu-Tao Weng,Hongping Zhang, Youhong Tang, Fuzeng Ren, Cancan Zhao, Guoxing Sun, Rui Liang, Zongjin Li,Mussel-inspired adhesive and tough hydrogel based on nanoclay confined dopamine polymerization, ACS Nano2017, 11, 2561-2574. (ESI 高被引文章)

20.Lu Han, Xiong Lu*, Menghao Wang, Donglin Gan, Weili Deng, Kefeng Wang, Liming Fang, Kezhi Liu, Chun Wai Chan, Youhong Tang, Lu-Tao Weng, Huipin Yuan, A mussel-inspired conductive, self-adhesive, and self-healable tough hydrogel as cell stimulators and implantable bioelectronics, Small2017, 13, 1601916. (ESI 高被引文章)

21.Lu Han, Liwei Yan, Kefeng Wang, Liming Fang, Hongping Zhang, Youhong Tang, Yonghui Ding, Lu-Tao Weng, Jielong Xu, Jie Weng, Yujie Liu, Fuzeng Ren*, Xiong Lu*, Tough, self-healable and tissue adhesive hydrogel with tunable multifunctionality, NPG Asia Materials2017, 9, e372. (ESI 高被引文章)

授权国家发明专利

1.     韩璐,刘迪,李肖壮,高静娴,吴雪玲, 一种琼脂糖基人工角膜及其制备方法. 中国，202311646607.2.

2.     崔家喜, 韩璐,一种提高水凝胶水下粘附能力的方法和相关水凝胶及其制备方法. 中国, 201910679909.7

3.     鲁雄, 韩璐, 王振铭, 董丽, 谢超鸣, 刘敏, 孙洪龙, 一种用于皮肤及内粘膜受损部位敷料的制备方法. 中国, 201410064266.2

4.     鲁雄,韩璐, 甘东林, 刘柯志, 王振铭, 谢超鸣, 一种自粘附导电水凝胶的制备方法. 中国,201610263508.X

项目课题

1.     国家自然科学基金青年项目，主持。

2.     山东省优秀青年科学基金项目，主持

3.     绿色防控重大专项，课题负责人

4.     重点实验室开放课题，主持

5.     中国海洋大学“青年英才工程”第一层次基金，主持。

6.     崂山实验室创新人才引进项目，主持。

7.     中国海洋大学优秀青年科技人才培育基金，主持