付鹏

付 鹏

博士

教授

博士生导师

科 室：

海洋天然药物化学研究室

电子邮箱：

fupeng@ouc.edu.cn

联系地址：

山东省青岛市市南区鱼山路5号中国海洋大学医药学院266003

研究方向：

海洋微生物天然药物化学与化学生物学

个人简介

主要围绕海洋放线菌资源开展功能导向的次级代谢产物研究，从中发现具有潜在药用价值的先导化合物分子，并探索代谢产物生物合成中非酶催化的化学过程，以此为指导实现天然产物结构的化学进化，为深入的化学生物学研究奠定基础。主持承担国家自然科学基金、中央高校基本科研业务费专项、中国海洋大学“青年英才工程”人才项目等多项研究课题。以第一或通讯作者在Nat. Commun.、Nat. Prod. Rep.、ACS Sustainable Chem. Eng.、Org. Lett.、Chinese Chem. Lett.、Org. Chem. Front.、J. Nat. Prod.等本领域主流期刊上发表SCI收录论文30余篇。

教育背景

2008.09~2013.06

中国海洋大学

药物化学

博士（硕博连读）

2004.09~2008.06

中国海洋大学

药学

学士

工作经历

2017.08~今

中国海洋大学 医药学院

教授

2013.07~2017.06

The University of Texas Southwestern Medical Center

博士后

承担课程

天然药物化学（本科生课程）

代表性成果

代表性论文（近5年）

1.         Shupeng Yin#, Zhi Liu#, Jingjing Shen, Yuwei Xia, Weihong Wang, PengyanGui, Qian Jia, KonthornKachanuban, Weiming Zhu*, and Peng Fu*. Chimeric natural products derived from medermycin and the nature-inspired construction of their polycyclic skeletons.Nat. Commun., 2022, 13, 5169.

2.         Yaqin Fan, Jingjing Shen, Zhi Liu, Kunyu Xia, Weiming Zhu*, and Peng Fu*. Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis. Nat. Prod. Rep., 2022, 39, 1305–1324.

3.         Shuige Zhao, Yuwei Xia, Haishan Liu, Tongxu Cui, Peng Fu*, and Weiming Zhu*. A Cyclohexapeptide and Its Rare Glycosides from Marine Sponge-Derived Streptomyces sp. OUCMDZ-4539. Org. Lett., 2022,24,6750–6754.（封面文章）

4.         Rongxin Zhang, Xiaotang Yan, Shupeng Yin, Weihong Wang, Weiming Zhu, and Peng Fu*. Discovery of New Bohemamines and Synthesis of Methylene Methylene-Bridged Chimeric Derivatives through Natural Product Chimera Strategy. Chin. J. Chem., 2022, 40, 1413–1421.

5.         Zhi Liu, Shupeng Yin, Rongxin Zhang, Weiming Zhu, and Peng Fu*. High-Efficiency Synthesis of Carbon-Bridged Dimers via Bioinspired Green Dimerization Involving Aldehydes. ACS Sustainable Chem. Eng., 2022, 10, 655–661.

6.         Mengmeng Lan#, Tongxu Cui#, Kaichun Xia, Guodong Cui, Yiwen Chu, Peng Fu*, and Weiming Zhu*. (±)-Pyriindolin with a 2,2′-Bipyridine-spiro[furan-3,3′-indoline] Chimeric Skeleton from the Endophytic Streptomyces albolongus EA12432. Chin. Chem. Lett., 2022,33,508–510.

7.         Rui Ma, Shan Cheng, Jiwen Sun, Weiming Zhu*, and Peng Fu*. Antibacterial Gilvocarcin-Type Aryl‑C‑Glycosides from a Soil-Derived Streptomyces Species. J. Nat. Prod., 2022, 85,2282–2289.

8.         Kunyu Xia, Hui Luo, Rui Ma, Rongxin Zhang, Weiming Zhu*, and Peng Fu*. Aromatic Polyketides and Hydroxamate Siderophores from a Marine-Algae-Derived Streptomyces Species. J. Nat. Prod., 2021, 84,1550–1555.

9.         Jingjing Shen, Jie Wang, Hao Chen, Yi Wang, Weiming Zhu*, and Peng Fu*. Cyclamenols E and F, Two DiastereoisomericBicyclic Macrolactams with a Cyclopentane Moiety from an Antarctic Streptomyces species. Org. Chem. Front., 2020, 7,310–317.

10.     Jingjing Shen#, Yaqin Fan#, Guoliang Zhu, Hao Chen, Weiming Zhu*, and Peng Fu*. Polycyclic Macrolactams Generated via Intramolecular Diels−Alder Reactions from an Antarctic Streptomyces Species. Org. Lett., 2019,21,4816–4820.

11.     Yanqin Fan, Yi Wang, Peng Fu*, ArthitChairoungdua, PawineePiyachaturawat, and Weiming Zhu*. Secopaxilline A, an Indole-Diterpenoid Derivative from an Aciduric Penicillium Fungus, its Identification and Semisynthesis.Org. Chem. Front., 2018, 5, 2835–2839.

12.     Yanqin Fan#, Cong Wang#, Liping Wang, ArthitChairoungdua, PawineePiyachaturawat, Peng Fu*, and Weiming Zhu*. New Ansamycins from the Deep-Sea-DerivedBacterium Ochrobactrum sp. OUCMDZ-2164.Mar. Drugs, 2018, 16,282.

13.     Yuqi Du, Jian Sun, Qianhong Gong, Yi Wang, Peng Fu*, and Weiming Zhu*. Newα-Pyridones with Quorum-Sensing Inhibitory Activity fromDiversity-Enhanced Extracts of a Streptomyces sp. Derived fromMarine Algae. J. Agric. Food Chem.2018, 66, 1807–1812.

14.      Guoliang Zhu#, Fandong Kong#, Yi Wang, Peng Fu*, and Weiming Zhu*.Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635. Mar. Drugs, 2018, 16, 71.

出版专著

1. Peng Fu. Use of Isotope Labels for NMR and MS Studies in Natural Products. Hung-Wen (Ben) Liu, Tadhg P. Begley, Eds. Comprehensive Natural Products III, Chemistry and Biology. Elsevier Ltd. 2020.