付鹏

作者:蔡超时间:2019-08-26

博士

教授

士生导师

科 室:

海洋天然物化学研究室

电子邮箱

fupeng@ouc.edu.cn

 

联系地址:

山东省青岛市市南区鱼山路5号中国海洋大学医药学院266003

研究方向:

海洋微生物天然药物化学与化学生物学

个人简介

 

 

 

 

主要围绕海洋放线菌资源开展功能导向的次级代谢产物研究,从中发现具有潜在药用价值的先导化合物分子,并探索代谢产物生物合成中非酶催化的化学过程,以此为指导实现天然产物结构的化学进化,为深入的化学生物学研究奠定基础主持承担国家自然科学基金、中央高校基本科研业务费专项、中国海洋大学“青年英才工程”人才项目等研究课题。以第一或通讯作者在Nat. Prod. Rep.ACS Sustainable Chem. Eng.Org. Lett.Chem. Eur. J.Org. Chem. Front.J. Nat. Prod.等本领域主流期刊上发表SCI收录论文30余篇。

教育背景

 

 

 

 

2008.09~2013.06

中国海洋大学

药物化学

博士(硕博连读)

2004.09~2008.06

中国海洋大学

药学

学士

工作经历

 

 

 

 

2017.08~今

中国海洋大学 医药学院

教授

 

2013.07~2017.06

The University of Texas Southwestern Medical Center

博士后

 

承担课程

 

 

 

 

天然药物化学(本科生课程)

代表性成果

代表论文

 

 

 

 

1.         Yaqin Fan, Jingjing Shen, Zhi Liu, Kunyu Xia, Weiming Zhu*, and Peng Fu*. Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis. Nat. Prod. Rep., 2022, Advance Article. https://doi.org/10.1039/D2NP00022A

2.         Rongxin Zhang, Xiaotang Yan, Shupeng Yin, Weihong Wang, Weiming Zhu, and Peng Fu*. Discovery of New Bohemamines and Synthesis of Methylene Methylene-Bridged Chimeric Derivatives through Natural Product Chimera Strategy. Chin. J. Chem., 2022, 40, 1413–1421.

3.         Zhi Liu, Shupeng Yin, Rongxin Zhang, Weiming Zhu, and Peng Fu*. High-Efficiency Synthesis of Carbon-Bridged Dimers via Bioinspired Green Dimerization Involving Aldehydes. ACS Sustainable Chem. Eng., 2022, 10, 655–661.

4.         Mengmeng Lan#, Tongxu Cui#, Kaichun Xia, Guodong Cui, Yiwen Chu, Peng Fu*, and Weiming Zhu*. (±)-Pyriindolin with a 2,2′-Bipyridine-spiro[furan-3,3′-indoline] Chimeric Skeleton from the Endophytic Streptomyces albolongus EA12432. Chin. Chem. Lett., 2022,33,508–510.

5.         Kunyu Xia, Hui Luo, Rui Ma, Rongxin Zhang, Weiming Zhu*, and Peng Fu*. Aromatic Polyketides and Hydroxamate Siderophores from a Marine-Algae-Derived Streptomyces Species. J. Nat. Prod., 2021, 84,1550–1555.

6.         Jingjing Shen, Jie Wang, Hao Chen, Yi Wang, Weiming Zhu*, and Peng Fu*. Cyclamenols E and F, Two DiastereoisomericBicyclic Macrolactams with a Cyclopentane Moiety from an Antarctic Streptomyces species. Org. Chem. Front., 2020, 7,310317.

7.         Jingjing Shen#, Yaqin Fan#, Guoliang Zhu, Hao Chen, Weiming Zhu*, and Peng Fu*. Polycyclic Macrolactams Generated via Intramolecular Diels−Alder Reactions from an Antarctic Streptomyces Species. Org. Lett., 2019,21,4816–4820.

8.         Yanqin Fan, Yi Wang, Peng Fu*, ArthitChairoungdua, PawineePiyachaturawat, and Weiming Zhu*. Secopaxilline A, an Indole-Diterpenoid Derivative from an Aciduric Penicillium Fungus, its Identification and Semisynthesis.Org. Chem. Front., 2018, 5, 28352839.

9.         Yanqin Fan#, Cong Wang#, Liping Wang, ArthitChairoungdua, PawineePiyachaturawat, Peng Fu*, and Weiming Zhu*. New Ansamycins from the Deep-Sea-DerivedBacterium Ochrobactrum sp. OUCMDZ-2164.Mar. Drugs, 2018, 16,282.

10.     Yuqi Du, Jian Sun, Qianhong Gong, Yi Wang, Peng Fu*, and Weiming Zhu*. Newα-Pyridones with Quorum-Sensing Inhibitory Activity fromDiversity-Enhanced Extracts of a Streptomyces sp. Derived fromMarine Algae. J. Agric. Food Chem.2018, 66, 18071812.

11.      Guoliang Zhu#, Fandong Kong#, Yi Wang, Peng Fu*, and Weiming Zhu*.Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635. Mar. Drugs, 2018, 16, 71.

12.     Peng Fu and John B. MacMillan*. Carpatizine, a Novel Bridged Oxazine Derivative Generated by Non-Enzymatic Reaction. Org. Biomol. Chem., 2017, 15,52755278.

13.     Peng Fu, Scott La, and John B. MacMillan*. DaryamideAnalogues from a Marine-Derived Streptomycesspecies. J. Nat. Prod., 2017, 80, 10961101.

14.     Peng Fu, Scott La, and John B. MacMillan*. 1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus. J. Nat. Prod., 2016, 79,455462.

15.     Peng Fu, Aaron Legako, Scott La, and John B MacMillan*. Discovery, Characterization, and Analogue Synthesis of Bohemamine Dimers Generated by Non-Enzymatic Biosynthesis. Chem. Eur. J.2016, 22, 34913495.

出版专著

 

 

 

 

1. Peng Fu. Use of Isotope Labels for NMR and MS Studies in Natural Products. Hung-Wen (Ben) Liu, Tadhg P. Begley, Eds. Comprehensive Natural Products III, Chemistry and Biology. Elsevier Ltd. 2020.






 

 

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